Effect of Magnesium Sulfate on the Total Anesthetic and Analgesic Requirements in Neurosurgery
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چکیده
Magnesium is necessary for the presynaptic release of acetylcholine from nerve endings and may produce effects similar to calciumentry-blocking drugs [1]. With the discovery of the N-methylD-aspartate (NMDA) receptor and its links to nociceptive pain transmission and central sensitization, there has been renewed interest in utilizing noncompetitive NMDA receptor antagonists, as potential antihyperalgesic agents. The magnesium ion was the first agent discovered to be an NMDA channel blocker. At high doses, perioperative intravenous magnesium sulfate has been reported to reduce postoperative morphine consumption. Therefore, when magnesium sulfate is co-administered with propofol, it potentiates the anesthetic effect and NMDA antagonism of propofol [2].
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